Beyond GLP-1: The Next Generation of Weight-Loss Drugs Is Already Here articles general nutrition metabolic health

Pharmaceutical treatment of obesity has changed the landscape of healthcare drastically. Within a remarkably short period, drugs such as semaglutide have moved from specialist diabetes clinics into everyday conversation, while the extraordinary commercial and cultural success of these medicines has ...

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Senolytics and Ageing: Have We Finally Seen Evidence That Clearing ‘Zombie Cells’ Can Help Humans? articles healthy ageing & longevity

Few areas of longevity research have generated quite as much excitement as senescent cells. They have acquired the wonderfully dramatic nickname “zombie cells”, are routinely presented as one of the villains of biological ageing, and have spawned an expanding market of supplements claiming to help t...

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Same Calories, Same Macros — So Why Did the Ultra-Processed Meal Produce a Different Metabolic Response articles general nutrition metabolic health

For decades, we have largely described food by breaking it down into its constituent parts. Calories, protein, carbohydrate, fat, fibre, vitamins and minerals are measured, printed neatly on the back of the packet and used to tell us something about the nutritional value of what we are about to eat....

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The Scales Can Lie: Why Maintaining Your Weight as You Age Doesn't Mean You're Maintaining Your Muscle articles general nutrition healthy ageing & longevity

This is one that always gets my goat. Simple measurements like weight on the scale or even BMI (Banal, Meaningless, Irrelevant - that is my nickname for it) serve as little more than sticks to beat ourselves with. 

For decades we have been conditioned to regard body weight as one of the great arbit...

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Ultra-Processed Foods and Health: Is Processing Really the Problem? articles general nutrition

Ultra-processed food has become a massive conversation piece lately. If you ever want to get a group of healthcare professionals bickering like Tom and Jerry after 7 coffees, then just bring up this subject and watch the fireworks. It is a hotbed. Depending on which side of the debate you encounter,...

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Can Your Diet Really Slow Biological Ageing? What the Latest Epigenetic Research Actually Shows articles general nutrition healthy ageing & longevity

The idea that we possess two different ages has become one of the most compelling concepts in longevity science. There is our chronological age, determined simply by the number of years we have been alive, and then there is our supposed biological age, an attempt to quantify how rapidly the tissues ...

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NMN Raises NAD+ — But Does It Actually Slow Ageing? articles general nutrition healthy ageing & longevity

NMN is definitely one of the most talked about supplements in recent times. It is a supplement that I personally take every single day and on a lot of metrics, it is one that has really moved the needle for me and one I would be loathe to remove from my protocol. It is marketed as an NAD+ booster an...

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How to Eat for a Longer, Healthier Life: What the Evidence Really Shows articles healthy ageing & longevity

The longevity field within nutrition is certainly advancing at a rate of knots and there are all manner of practices that promise the key to eternal youth. We are told that fasting can switch on our longevity genes, that certain supplements can slow biological ageing, that particular foods activate ...

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Why Am I Bloated All the Time? Understanding the Causes of Bloating and What Can Actually Help articles general nutrition gut health

Bloating is one of the most common digestive complaints, yet it is also one of the most poorly understood. For some people it means feeling excessively full after eating. For others it describes pressure, abdominal discomfort, excessive gas or a visibly distended abdomen that can change dramatically...

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How to Build a Healthier Gut: What the Science Actually Says articles general nutrition gut health

Gut health has become one of the biggest subjects in nutrition, and with that popularity has come an extraordinary amount of noise. We are now surrounded by microbiome tests, probiotic supplements, fermented drinks, “gut resets”, elimination diets and products promising to restore microbial balance....

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Eating Well on GLP-1s: The Nutritional Risks Nobody Should Ignore articles general nutrition metabolic health

Drugs such as semaglutide and tirzepatide have transformed the treatment of obesity. By profoundly reducing appetite and food intake, they can produce levels of weight loss that were previously difficult to achieve without surgery. But eating substantially less creates a nutritional challenge that d...

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Why Is It So Hard to Lose Weight? Understanding the Biology of Weight Loss articles general nutrition metabolic health

Losing weight is frequently presented as though it should be one of the simplest things in nutrition. Eat less, move more and maintain the resulting calorie deficit for long enough, and body weight should fall. At the level of basic physics, there is nothing particularly controversial about this. Re...

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